Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ For further information, see CMDT Part 32-07: Adenovirus Infections + Key Features Download Section PDF Listen +++ ++ At least 57 types, which produce a variety of clinical syndromes Usually self-limited except in immunosuppressed persons + Clinical Findings Download Section PDF Listen +++ ++ Common cold Nonstreptococcal exudative pharyngitis Lower respiratory tract infections Epidemic keratoconjunctivitis Hemorrhagic cystitis Acute gastroenteritis Disseminated disease in transplant recipients + Diagnosis Download Section PDF Listen +++ ++ Can be cultured from appropriate specimens when definitive diagnosis is desired Quantitative real-time rapid-cycle PCR useful in distinguishing disease from colonization, especially in hematopoietic stem cell transplant patients Multiplex nucleic acid amplification assays can test for multiple respiratory viruses simultaneously with increased sensitivity Appears as a multifocal consolidation or ground-glass opacity without airway inflammatory findings on chest CT imaging + Treatment Download Section PDF Listen +++ ++ Disease usually self-limited Immunocompromised patients often treated with ribavirin or cidofovir, with occasional success Cidofovir is attendant with significant renal toxicity and reduction in doses of immunosuppressive agents is often required Brincidofovir, a nucleoside analog Appears to be useful in patients infected after stem cell transplantation Only available through compassionate use policies Epidemic adenoviral conjunctivitis is often difficult to control and requires Meticulous attention to hand hygiene Use of disposable gloves Sterilization of equipment (isopropyl alcohol is insufficient, recommendations of manufacturers are preferred) Cohorting of cases Furloughing of employees A combination of povidone-iodine 1.0% eyedrops and dexamethasone 0.1% eyedrops four times a day can reduce symptoms and expedite recovery Intravenous immunoglobulin (IVIG) is used in immunocompromised persons but data are still limited