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Clinical trials have suggested an increase in all-cause mortality with high dose (greater than 400 international units/day) vitamin E supplements. Large doses of vitamin E can also increase the vitamin K requirement and can result in bleeding in patients taking oral anticoagulants.
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Kryscio
RJ
et al. Association of antioxidant supplement use and dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE). JAMA Neurol. 2017 May 1;74(5):567–73.
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Lloret
A
et al. The effectiveness of vitamin E treatment in Alzheimer's disease. Int J Mol Sci. 2019 Feb 18;20(4).
[PubMed: 30781638]
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Okebukola
PO
et al. Vitamin E supplementation in people with cystic fibrosis. Cochrane Database Syst Rev. 2017 Mar 6;3:CD009422.
[PubMed: 28262916]