The patient is placed in a chair with head tilted back, both eyes open, and looking up. With clean hands, the lower lid is retracted slightly, and 1–2 drops of liquid are instilled into the lower cul-de-sac. The patient then closes the eye. Gentle digital pressure, “punctal occlusion,” can be applied between the nose and the medial canthus for 1–3 minutes to close off the nasolacrimal duct and allow for maximum penetration of the eyedrop onto the ocular surface. Ointments are instilled in the same general manner. Punctal occlusion is not required for ointments.