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Key Clinical Updates in Fever & Hyperthermia

In a study of trauma patients, there was a significant association between the presence of early fever and death in the hospital as well as longer median intensive care unit stays.

There is increasing evidence that postoperative atelectasis does not cause fever. However, febrile nonhemolytic transfusion reaction is common.


  • Age; injection substance use.

  • Localizing symptoms; weight loss; joint pain.

  • Immunosuppression or neutropenia; history of cancer.

  • Medications.

  • Travel.


The average normal oral body temperature taken in mid-morning is 36.7°C (range 36–37.4°C). This range includes a mean and 2 standard deviations, thus encompassing 95% of a normal population (normal diurnal temperature variation is 0.5–1°C). The normal rectal or vaginal temperature is 0.5°C higher than the oral temperature, and the axillary temperature is 0.5°C lower. Interestingly, in a pooled meta-analysis comparing peripheral with central body temperature measurement, peripheral thermometers (tympanic membrane, temporal artery, axillary, oral) showed low sensitivity but high specificity. This suggests that a normal body temperature based on a peripheral measurement does not always exclude the presence of a fever. Thus, to exclude a fever, a rectal temperature is more reliable than an oral temperature (particularly in patients who breathe through their mouth or are tachypneic or who are in an intensive care unit setting where a rectal temperature probe can be placed to detect fever). Wearable digital thermometers may detect early mild increased temperature in patients with low white blood cell counts.

Fever is a regulated rise to a new “set point” of body temperature in the hypothalamus induced by pyrogenic cytokines. These cytokines include interleukin-1 (IL-1), tumor necrosis factor (TNF), interferon-gamma, and interleukin-6 (IL-6). The elevation in temperature results from either increased heat production (eg, shivering) or decreased heat loss (eg, peripheral vasoconstriction). Body temperature in cytokine-induced fever seldom exceeds 41.1°C unless there is structural damage to hypothalamic regulatory centers.


A. Fever

Fever as a symptom provides important information about the presence of illness—particularly infections—and about changes in the clinical status of the patient. Fever may be more predictive of bacteremia in elderly patients. The fever pattern, however, is of marginal value for most specific diagnoses except for the relapsing fever of malaria, borreliosis, and occasional cases of lymphoma, especially Hodgkin disease. Furthermore, the degree of temperature elevation does not necessarily correspond to the severity of the illness. Contrary to common perceptions, a Swedish study found that increased body temperature in the emergency department was strongly associated with lower mortality and shorter hospital stays in patients with severe sepsis or septic shock subsequently admitted to the intensive care unit even after adjustment for quality of care measures. Fever, with rash and eosinophilia, define the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.

In general, the febrile response ...

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