NEPHRITIC SPECTRUM GLOMERULAR DISEASES
For IgA nephropathy, mycophenolate mofetil has shown promise in a Chinese population, but not in whites, suggesting a possible impact of ethnicity on disease behavior or therapy effect
Hydroxychloroquine was recently shown in a small randomized trial to decrease proteinuria over the 6-month follow-up.
In SLE, repeat renal biopsy yields more reliable information regarding disease activity than do disease activity markers (double-stranded DNA antibodies, serum C3, C4, CH50 levels), the urinary protein levels, and sediment activity; biopsy, therefore, may be used to guide maintenance therapy withdrawal.
The presence of elevated levels of circulating PLA2R antibodies, which are considered diagnostic for idiopathic membranous nephropathy, may eliminate the need for kidney biopsy.