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For further information, see CMDT Part 29-10: Riboflavin (B2) Deficiency

Key Features

  • Almost always occurs in combination with deficiencies of other vitamins

  • Caused by dietary inadequacy, interactions with a variety of medications, alcoholism, and other causes of protein-calorie undernutrition

Clinical Findings

  • Cheilosis, angular stomatitis, glossitis

  • Seborrheic dermatitis

  • Weakness

  • Corneal vascularization

  • Anemia

Diagnosis

  • Measure serum levels of the riboflavin-dependent enzyme erythrocyte glutathione reductase. Activity coefficients > 1.2–1.4 suggest riboflavin deficiency

  • Urinary riboflavin excretion and serum levels of plasma and red blood cell flavins can also be measured

Treatment

  • Riboflavin, 5–15 mg orally once daily, until clinical findings are resolved

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