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Clinical trials have suggested an increase in all-cause mortality with high dose (400 international units/day or more) vitamin E supplements. Large doses of vitamin E can also increase the vitamin K requirement and can result in bleeding in patients taking oral anticoagulants.

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Kryscio  RJ  et al. Association of antioxidant supplement use and dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE). JAMA Neurol. 2017 May 1;74(5):567–73.
[PubMed: 28319243]  
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Lloret  A  et al. The effectiveness of vitamin E treatment in Alzheimer’s disease. Int J Mol Sci. 2019 Feb 18;20(4).
[PubMed: 30781638]
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Okebukola  PO  et al. Vitamin E supplementation in people with cystic fibrosis. Cochrane Database Syst Rev. 2017 Mar 6;3:CD009422.
[PubMed: 28262916]  

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