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Symptoms of excess vitamin B6 supplementation can be similar to those of vitamin B6 deficiency. A sensory neuropathy, at times irreversible, occurs in patients receiving large doses of vitamin B6 (200–2000 mg/day).

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Van Arsdale  S  et al. Pyridoxine deficiency after solid organ transplant. Prog Transplant. 2017 Sep;27(3):251–6.
[PubMed: 29187089]  
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Vrolijk  MF  et al. The vitamin B6 paradox: supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017 Oct;44:206–12.
[PubMed: 28716455]  

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