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At the high doses of niacin used to treat hyperlipidemia, side effects are common. These include cutaneous flushing (partially prevented by pretreatment with aspirin, 81–325 mg/day, and use of extended-release preparations) and gastric irritation. Elevation of liver enzymes, hyperglycemia, and gout are less common untoward effects.

Goldie  C  et al. Niacin therapy and the risk of new-onset diabetes: a meta-analysis of randomised controlled trials. Heart. 2016 Feb;102(3):198–203.
[PubMed: 26370223]  
Shaughnessy  AF. Niacin does not decrease mortality in patients with coronary artery disease or low HDL. Am Fam Physician. 2017 Jul 15;96(2):129.
[PubMed: 28762704]  
Streja  E  et al. Niacin and progression of CKD. Am J Kidney Dis. 2015 May;65(5):785–98.
[PubMed: 25708553]  
Superko  HR  et al. Niacin and heart disease prevention: engraving its tombstone is a mistake. J Clin Lipidol. 2017 Nov–Dec;11(6):1309–17.
[PubMed: 28927896]  

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