ESSENTIALS OF DIAGNOSIS
Low bone density from defective mineralization.
Caused by deficiency in calcium, phosphorus, or low alkaline phosphatase.
Rickets: defective bone mineralization in childhood or adolescence before epiphyseal fusion.
Osteomalacia: defective bone mineralization in adults with fused epiphyses.
Painful proximal muscle weakness (especially pelvic girdle); bone pain.
Low 25-hydroxy-vitamin D (25-OHD), hypocalcemia, hypocalciuria, hypophosphatemia, secondary hyperparathyroidism.
Classic radiologic features may be present.
Defective mineralization of the growing skeleton in childhood causes permanent bone deformities (rickets). Defective skeletal mineralization in adults is known as osteomalacia. It is caused by any condition that results in inadequate calcium or phosphate mineralization of bone osteoid.
Table 26–10.Causes of osteomalacia.1 ||Download (.pdf) Table 26–10. Causes of osteomalacia.1
Insufficient sunlight exposure
Kidney: chronic kidney disease, nephrotic syndrome, kidney transplantation
Nutritional deficiency of vitamin D
Malabsorption: aging, excess wheat bran, bariatric surgery, pancreatic enzyme deficiency, orlistat
Vitamin D–dependent rickets type I
Phenytoin, carbamazepine, valproate, or barbiturate therapy (long-term)
Dietary calcium deficiency
Fanconi syndrome, renal tubular acidosis, and alcoholism
Nutritional deficiency of phosphorus
Phosphate-binding antacid therapy
Tumoral hypophosphatemic osteomalacia
X-linked hypophosphatemic rickets
Other disorders, including paraproteinemias, glycogen storage diseases, neurofibromatosis, Wilson disease
Inhibitors of mineralization
Disorders of bone matrix
A. Vitamin D Deficiency and Resistance
Vitamin D is predominantly synthesized in the skin during exposure to ultraviolet B light (Table 26–10). Vitamin D is also consumed in the diet from plants (ergocalciferol, D2) or animals/fish (cholecalciferol, D3). Both forms of vitamin D are converted in the liver to 25-hydroxyvitamin D (25-OHD); 25-OHD is subsequently converted in various tissues (mainly kidney) to 1,25-dihydroxyvitamin D (1,25[OH]2D), the active hormone whose production is regulated by serum calcium, phosphorus, and PTH. 1,25(OH)2D binds to cytoplasmic vitamin D receptors, increasing the absorption of dietary calcium from the intestine and increasing the reabsorption of calcium in the renal tubule, thereby reducing calcium loss in the urine. 1,25(OH)2D also stimulates bone osteoblasts to release RANKL that stimulates osteoclasts, which release calcium from bone.
Vitamin D deficiency is the most common cause of osteomalacia; its incidence is increasing throughout the world as a result of diminished exposure to sunlight caused by urbanization, automobile and public transportation, modest clothing, and sunscreen use. About 36% of adults in the United States are deficient in vitamin D.
Vitamin D deficiency is most commonly caused by insufficient sunlight exposure from living at high latitudes, winter season, institutionalization, wearing sun protection, or very modest dressing. Other risk factors for vitamin D deficiency include the following: pregnant women, ...