ESSENTIALS OF DIAGNOSIS
Decline in the GFR over months to years.
Persistent proteinuria or abnormal renal morphology may be present.
Hypertension in most cases.
Symptoms and signs of uremia when nearing end-stage disease.
Bilateral small or echogenic kidneys on ultrasound in advanced disease.
CKD affects at least 10% of Americans. Many may be unaware of the condition because they remain asymptomatic until the disease is near end stage. The National Kidney Foundation's staging system helps clinicians formulate practice plans (Table 22–4). Over 70% of cases of late-stage CKD (stage 5 CKD and ESRD) in the United States are due to diabetes mellitus or hypertension/vascular disease. Glomerulonephritis, cystic diseases, chronic tubulointerstitial diseases, and other urologic diseases account for the remainder (Table 22–5). Genetic polymorphisms of the APOL-1 gene have been shown to be associated with an increased risk of the development of CKD in persons of African descent.
Table 22–4.Stages of chronic kidney disease: a clinical action plan.1,2 ||Download (.pdf) Table 22–4. Stages of chronic kidney disease: a clinical action plan.1,2
|Stage3 ||Description ||GFR (mL/min/1.73 m2) ||Action |
|1 ||Kidney damage with normal or ↑↑ GFR ||≥ 90 ||Diagnosis and treatment of underlying etiology if possible. Treatment of comorbid conditions. Estimate progression, work to slow progression. Cardiovascular disease risk reduction. |
|2 ||Kidney damage with mildly ↓ GFR ||60–89 |
|3a ||Mildly-moderately ↓ GFR ||45–59 ||As above, and evaluating and treating complications. |
|3b ||Moderately-severely ↓ GFR ||30–44 |
|4 ||Severely ↓ GFR ||15–29 ||Preparation for end-stage renal disease. |
|5 ||End-stage renal disease ||< 15 (or dialysis) ||Dialysis, transplant, or palliative care. |
Table 22–5.Major causes of chronic kidney disease. ||Download (.pdf) Table 22–5. Major causes of chronic kidney disease.
|Glomerular Diseases |
Primary glomerular diseases
Focal segmental glomerulosclerosis
Alport syndrome (hereditary nephritis)
Secondary glomerular diseases