Skip to Main Content

Fresh frozen plasma (FFP) is available in units of approximately 200 mL. FFP contains normal levels of all coagulation factors (about 1 unit/mL of each factor). FFP is used to correct coagulation factor deficiencies and to treat thrombotic thrombocytopenia purpura or other thrombotic microangiopathies. FFP is also used to correct or prevent coagulopathy in trauma patients receiving massive transfusion of PRBC. An FFP:PRBC ratio of 1:2 or more is associated with improved survival in trauma patients receiving massive transfusions, regardless of the presence of a coagulopathy.

Cryoprecipitate is made from fresh plasma by cooling the plasma to 4°C and collecting the precipitate. One unit of cryoprecipitate has a volume of approximately 15–20 mL and contains approximately 250 mg of fibrinogen and between 80 and 100 units of factor VIII and von Willebrand factor. Cryoprecipitate is most commonly used to supplement fibrinogen in cases of acquired hypofibrinogenemia (eg, DIC) or in rare instances of congenital hypofibrinogenemia. One unit of cryoprecipitate will raise the fibrinogen level by about 8 mg/dL (0.24 mcmol/L). Cryoprecipitate is sometimes used to temporarily correct the acquired qualitative platelet dysfunction associated with kidney disease.

Bryan  AW Jr  et al. Plasma transfusion demystified: a review of the key factors influencing the response to plasma transfusion. Lab Med. 2017 May 1;48(2):108–12.
[PubMed: 28444398]
Christou  G  et al. Optimal transfusion practices after allogeneic hematopoietic cell transplantation: a systematic scoping review of evidence from randomized controlled trials. Transfusion. 2016 Oct;56(10):2607–14.
[PubMed: 27465524]
Fasano  RM  et al. Platelet transfusion goals in oncology patients. Hematology Am Soc Hematol Educ Program. 2015;2015:462–70.
[PubMed: 26637759]  
Goodnough  LT  et al. Blood transfusion therapy. Med Clin North Am. 2017 Mar;101(2):431–47.
[PubMed: 28189180]
Hoeks  MPA  et al. Impact of red blood cell transfusion strategies in haemato-oncological patients: a systematic review and meta-analysis. Br J Haematol. 2017 Jul;178(1):137–51.
[PubMed: 28589623]
Kaufman  RM  et al. Platelet transfusion: a clinical practice guideline from the AABB. Ann Intern Med. 2015 Feb 3;162(3):205–13.
[PubMed: 25383671]
Marfin  AA  et al. Granulocyte transfusion therapy. J Intensive Care Med. 2015 Feb;30(2):79–88.
[PubMed: 23920161]
Prescott  LS  et al. How low should we go: a systematic review and meta-analysis of the impact of restrictive red blood cell transfusion strategies in oncology. Cancer Treat Rev. 2016 May;46:1–8.
[PubMed: 27046422]
Tariket  S  et al. Transfusion-related acute lung injury: transfusion, platelets and biological response modifiers. Expert Rev Hematol. 2016 May;9(5):497–508.
[PubMed: 26855042]

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.