Skip to Main Content

ESSENTIALS OF DIAGNOSIS

  • Noninflammatory blisters on sun-exposed sites, especially the dorsal surfaces of the hands.

  • Hypertrichosis, skin fragility.

  • Associated liver disease.

  • Elevated urine porphyrins.

GENERAL CONSIDERATIONS

Porphyria cutanea tarda is the most common type of porphyria. Cases are sporadic or hereditary. The disease is associated with ingestion of certain medications (eg, estrogens) and alcoholic liver disease, hemochromatosis, or hepatitis C.

CLINICAL FINDINGS

A. Symptoms and Signs

Patients complain of painless blistering and fragility of the skin of the dorsal surfaces of the hands (Figure 6–16). Facial hypertrichosis and hyperpigmentation are common.

Figure 6–16.

Porphyria cutanea tarda. (Used, with permission, from Lewis Rose, MD, in Usatine RP, Smith MA, Mayeaux EJ Jr, Chumley H, Tysinger J. The Color Atlas of Family Medicine. McGraw-Hill, 2009.)

B. Laboratory Findings

Urinary uroporphyrins are elevated twofold to fivefold above coproporphyrins. Patients may also have abnormal liver biochemical tests, evidence of hepatitis C infection, increased liver iron stores, and hemochromatosis gene mutations.

DIFFERENTIAL DIAGNOSIS

Skin lesions identical to those of porphyria cutanea tarda may be seen in patients who undergo dialysis and in those who take certain medications (tetracyclines, voriconazole, and NSAIDs, especially naproxen). In this so-called pseudoporphyria, the biopsy results are the same as those associated with porphyria cutanea tarda, but urine porphyrins are normal.

PREVENTION

Barrier sun protection with clothing is required. Although the lesions are triggered by sun exposure, the wavelength of light triggering the lesions is beyond that absorbed by sunscreens.

TREATMENT

Stopping all triggering medications and substantially reducing or stopping alcohol consumption may alone lead to improvement in most cases. Phlebotomy without oral iron supplementation at a rate of 1 unit every 2–4 weeks will gradually lead to improvement. Very low-dose antimalarial medication (as low as 200 mg of hydroxychloroquine orally twice weekly), alone or in combination with phlebotomy, will increase the excretion of porphyrins, improving the skin disease. Deferasirox, an iron chelator, can also improve porphyria cutanea tarda. Treatment is continued until the patient is asymptomatic. Urine porphyrins may be monitored.

PROGNOSIS

Most patients improve with treatment. Sclerodermoid skin lesions may develop on the trunk, scalp, and face.

+
Handler  NS  et al. Porphyria cutanea tarda: an intriguing genetic disease and marker. Int J Dermatol. 2017 Jun;56(6):e106–17.
[PubMed: 28321838]

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.