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Chapter 42. Rabies, Slow Virus Infections, and Prion Diseases

Rabies virus is rapidly destroyed by

(A) Ultraviolet radiation

(B) Heating at 56°C for 1 hour

(C) Ether treatment

(D) Trypsin treatment

(E) All of the above

Prions are readily destroyed by

(A) Ionizing radiation

(B) Formaldehyde

(C) Boiling

(D) Proteases

(E) None of the above

The presence in neurons of eosinophilic cytoplasmic inclusion bodies, called Negri bodies, is characteristic of which of the following central nervous system infections?

(A) Borna disease

(B) Rabies

(C) Subacute sclerosing panencephalitis

(D) New variant Creutzfeldt-Jakob disease

(E) Postvaccinal encephalitis

Which of the following statements about rabies vaccines for human use is true?

(A) Contain live, attenuated rabies virus

(B) Contain multiple antigenic types of rabies virus

(C) Can treat clinical cases of rabies

(D) Can be used for postexposure prophylaxis

(E) They are associated with Guillain-Barré syndrome.

A 22-year-old man is a resident of a small town near London. He likes to eat beefsteak. He develops a severe progressive neurologic disease characterized by psychiatric symptoms, cerebellar signs, and dementia. Probable bovine spongiform encephalopathy (BSE) is diagnosed. New variant Creutzfeldt-Jakob disease in humans and BSE appear to be caused by the same agent. Which of the following statements is true of both diseases?

(A) Immunosuppression of the host is a predisposing factor.

(B) It is an immune-mediated degenerative neurologic disorder.

(C) There is a long incubation period (months to years) from time of exposure to appearance of symptoms.

(D) The agent is recoverable only from the central nervous system of an infected host.

(E) The interferon response persists throughout the incubation period.

(F) There is a high-titer antibody response toward PrPSc protein of the ...

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