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Chapter 33. Herpesviruses

A previously healthy 3-year-old boy develops a classic viral childhood illness. Which of the following primary viral infections of childhood is usually symptomatic?

(A) Cytomegalovirus

(B) Epstein-Barr virus

(C) Hepatitis B virus

(D) Varicella-zoster virus

(E) Parvovirus B19

Which one of the following is a recommended therapy for herpes simplex virus genital infection?

(A) Acyclovir

(B) Attenuated live virus vaccine

(C) Herpes immune globulin

(D) Interferon-α

(E) Ribavirin

Most herpesvirus infections are endemic worldwide. Which one of the following viruses shows marked geographic differences in seroprevalence?

(A) Cytomegalovirus

(B) Epstein-Barr virus

(C) Herpes simplex virus type 2

(D) Kaposi sarcoma herpesvirus

(E) Varicella-zoster virus

A 19-year-old female college student has a fever, sore throat, and lymphadenopathy accompanied by lymphocytosis with atypical cells and an increase in sheep cell agglutinins. The diagnosis is most likely

(A) Infectious hepatitis

(B) Infectious mononucleosis

(C) Chickenpox

(D) Herpes simplex infection

(E) Viral meningitis

A Tzanck smear of a scraping obtained from a vesicle on the skin demonstrates multinucleated giant cells. Multinucleated giant cells are associated with which of the following viruses?

(A) Varicella-zoster

(B) Variola major

(C) Coxsackievirus

(D) Molluscum contagiosum

Which of the following statements about betaherpesviruses is not true?

(A) They establish latent infections and persist indefinitely in infected hosts.

(B) They are reactivated in immunocompromised patients.

(C) Most infections are subclinical.

(D) They can infect lymphoid cells.

(E) They have short, cytolytic growth cycles in cultured cells.

A 28-year-old ...

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