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Chapter 30. Pathogenesis and Control of Viral Diseases

Interferons are an important part of the host defense against viral infections. What is interferon’s principal mode of action?

(A) It is present in the serum of healthy individuals, providing a viral surveillance role.

(B) It coats viral particles and blocks their attachment to cells.

(C) It induces synthesis of one or more cellular proteins that inhibit translation or transcription.

(D) It protects the virus-infected cell that produced it from cell death.

A 9-month-old girl is taken to the emergency room because of fever and persistent cough. Rales are heard in her left chest on physical examination. An infiltrate in her left lung is seen on the chest radiograph. Pneumonia is diagnosed. Which of the following is the most likely cause?

(A) Rotavirus

(B) Rhinovirus

(C) Adenovirus

(D) Respiratory syncytial virus

(E) Coxsackievirus

Which one of the following is a fundamental principle of viral disease causation?

(A) One virus type induces a single disease syndrome.

(B) Many viral infections are subclinical and do not produce clinical disease.

(C) The type of disease produced by a virus can be predicted by the morphology of that virus.

(D) A particular disease syndrome has a single viral cause.

The skin is a formidable barrier to virus entry, but a few viruses are able to breach this barrier and initiate infection of the host. Which of the following is an example of a virus that enters through skin abrasions?

(A) Adenovirus

(B) Rotavirus

(C) Rhinovirus

(D) Papilloma virus

(E) Influenza virus

A 40-year-old man has HIV/AIDS characterized by a low CD4 count and a high viral load. Highly active antiretroviral therapy (HAART) will be initiated. One of the drugs under consideration is a nucleoside analog that inhibits viral reverse transcriptase and is active against both HIV and hepatitis B virus. That drug is

(A) Acyclovir

(B) Amantadine


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