Melena, hematemesis, hemoptysis, fresh blood in stool, musculoskeletal bleeding, or soft tissue bleeding not requiring red cell transfusion within 24 h of onset and without hemodynamic instability Profuse epistaxis or oropharyngeal bleeding >30 min Symptomatic oral blood blisters, ie, bleeding or causing major discomfort Multiple bruises, each >2 cm or any one >10 cm Petechiae/purpura that is diffuse Visible blood in urine Abnormal bleeding from invasive or procedure sites Unexpected vaginal bleeding saturating more than 2 pads with blood in a 24-h period Bleeding in cavity fluids evident macroscopically Retinal hemorrhage without visual impairment |