USPSTF 2015, AAFP 2014, ACOG 2008, CDC 1998.
Insufficient evidence to recommend for or against routine screening for iron deficiency anemia (IDA) in pregnant women to prevent adverse maternal or birth outcomes. Insufficient evidence to recommend for or against use of iron supplements for non-anemic pregnant women. (USPSTF, 2015)
When acute stress or inflammatory disorders are not present, a serum ferritin level is the most accurate test for evaluating IDA. Among women of childbearing age, a cutoff of 30 ng/mL has sensitivity of 92%, specificity of 98%. (Blood. 1997;89:1052-1057)
Oral iron is first line therapy for IDA in pregnancy. IV iron is preferred choice (after 13th week) for those who have oral iron intolerance. Cobalamin and folate deficiency should be excluded. (Blood. 2017;129:940-949)
Decision to transfuse should be based on the hemoglobin, clinical context, and patient preferences. May be appropriate in severe anemia (<7 mg/dL according to WHO) in whom a 2-wk delay in Hb rise with oral iron may result in significant morbidity.
CDC 2015, AAFP 2012, AAP/ACOG 2012