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Key Features

Essentials of Diagnosis

  • History of or predisposition to aspiration

  • Indolent symptoms, including fever, weight loss, malaise

  • Poor dentition

  • Foul-smelling purulent sputum (in many patients)

  • Opacity in dependent lung zone, with single or multiple areas of cavitation or pleural effusion

General Considerations

  • Nocturnal aspiration of small amounts of oropharyngeal secretions is typically not pathologic

  • Larger aspirations may cause

    • Nocturnal asthma

    • Chemical pneumonitis

    • Bronchiectasis

    • Mechanical obstruction

    • Pleuropulmonary infection

  • Predisposing factors include

    • Drug or alcohol use

    • Seizures

    • Anesthesia

    • CNS disease

    • Trachea or nasogastric tubes

  • Periodontal disease and poor oral hygiene are associated with a greater likelihood of pleuropulmonary infection

  • Disease usually occurs in dependent lung zones

  • Most infections include multiple anaerobic bacteria

    • Prevotella melaninogenica

    • Peptostreptococcus

    • Fusobacterium nucleatum

    • Bacteroides

Clinical Findings

Symptoms and Signs

  • Onset is insidious; necrotizing pneumonia, abscess, or empyema may be apparent at presentation

  • Constitutional symptoms of fever, malaise, and weight loss are common

  • Cough with foul-smelling expectorant suggests anaerobic infection

  • Poor dentition is typical; patients are rarely edentulous

  • Occurrence in an edentulous patient suggests an obstructing bronchial lesion

Differential Diagnosis

  • Other causes of cavitary lung disease

    • Tuberculosis

    • Fungal infection

    • Bronchogenic cancer

    • Pulmonary infarction

    • Granulomatosis with polyangiitis (formerly Wegener granulomatosis)

    • Cavitary bacterial pneumonia

  • Fungal infection, eg, histoplasmosis

  • Bronchiectasis

Diagnosis

Laboratory Tests

  • Culture of expectorated sputum is not useful due to contamination with oral flora

Imaging Studies

  • Chest radiograph in a lung abscess shows a thick-walled cavity surrounded by consolidation, occasionally with an air-fluid level

  • Chest radiograph in necrotizing pneumonia demonstrates multiple areas of cavitation within an area of consolidation

  • Empyema is characterized by purulent pleural fluid and may accompany the findings of abscess or necrotizing pneumonia

  • Ultrasonography may identify loculations or help localize fluid for safe thoracentesis

Diagnostic Procedures

  • Representative material for culture can be obtained only by

    • Transthoracic aspiration

    • Thoracentesis

    • Bronchoscopy with a protected brush

Treatment

Medications

  • Clindamycin (600 mg every 8 hours intravenously, then 300 mg every 6 hours orally after initial improvement)

  • Amoxicillin-clavulanate (875 mg/125 mg every 12 hours orally)

  • Penicillin (amoxicillin 500 mg every 8 hours orally or penicillin G 1–2 million units every 4–6 hours intravenously) plus metronidazole 500 mg every 8–12 hours orally or intravenously

  • Penicillin alone is inadequate treatment

  • Therapy should be continued until the chest radiograph improves, usually for a month or more

Surgery

  • Open pleural drainage is sometimes needed because of loculations associated with a parapneumonic effusion

Therapeutic Procedures

  • Thoracentesis

  • Thoracostomy tube drainage for empyema in anaerobic pleuropulmonary infection

Outcome

Follow-Up

  • Monitor with ...

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