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PATIENT STORY

A 57-year-old farm worker presents with itchy red rings on his body that have come and gone for more than 13 years (Figures 215-1 and 215-2). The erythematous annular eruption was visible on his abdomen, legs, and arms. Figure 215-2 shows the typical "trailing scale" of erythema annulare centrifugum (EAC). A KOH preparation was negative for fungal elements, and the patient was given the diagnosis of EAC. He recently began using paint thinner to "dry out the rash" and decrease the itching. Because topical steroids did not provide any relief for him in the past, we offered the option of using calcipotriol ointment. He chose to try the calcipotriol and stop using paint thinner.

FIGURE 215-1

Erythema annulare centrifugum with large erythematous rings on the trunk and legs of a 57-year-old man. (Reproduced with permission from Brand ME, Usatine RP. Persistent itchy pink rings, J Fam Pract. 2005;54(2):131-133. Frontline Medical Communications. Inc..)

FIGURE 215-2

Erythema annulare centrifugum with conjoined rings on the thigh. Arrow pointing to "trailing scale," which appears as a white scaling line within the erythematous border. (Reproduced with permission from Brand ME, Usatine RP. Persistent itchy pink rings, J Fam Pract. 2005;54(2):131-133. Frontline Medical Communications. Inc..)

INTRODUCTION

EAC is an uncommon inflammatory skin disease characterized by slowly migrating annular or configurate erythematous lesions.

SYNONYMS

Erythema gyratum perstans, erythema exudativum perstans, erythema marginatum perstans, erythema perstans, erythema figuratum perstans, erythema microgyratum perstans, and erythema simplex gyratum.

EPIDEMIOLOGY

  • It may begin at any age (mean age of onset: 39.7 years), with no predilection for either sex.1

  • The mean duration of skin condition is 2.8 years but may last between 4 weeks and 34 years.2

ETIOLOGY AND PATHOPHYSIOLOGY

  • Unknown etiology and pathogenesis, but EAC has been associated with other medical conditions, such as fungal infections (in 72% of cases),1 malignancy, and other systemic illness. In one series of 66 patients, the most common underlying reported cause was tinea pedis.1 A few case reports have reported the diagnosis of cancer 2 years after presentation of EAC.2

  • Other infections identified as triggers for EAC include bacterial infections such as cystitis, appendicitis, and tuberculosis (TB); viral infections such as Epstein-Barr virus (EBV), molluscum contagiosum, and herpes zoster; and parasites, such as Ascaris.2

  • Certain drugs, such as chloroquine, hydroxychloroquine, estrogen, cimetidine, penicillin, salicylates, piroxicam, hydrochlorothiazide, amitriptyline, lenalidomide, finasteride, and etizolam, can also trigger EAC.2-6

  • Systemic diseases involving the liver, dysproteinemias, autoimmune disorders, HIV, and pregnancy are associated with EAC by various case reports.2,7,8

  • Because injections of Trichophyton, ...

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