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PATIENT STORY

A 28-year-old man presented with sudden onset of a right red eye, severe eye pain, tearing, photophobia, and decreased vision. He denied eye trauma. His review of systems was positive for lower back pain and stiffness over the past year. On examination, he had a ciliary flush (Figure 20-1) and decreased vision. He was referred to an ophthalmologist who confirmed the diagnosis of acute anterior uveitis. He was found to be HLA-B27 positive with characteristics of ankylosing spondylitis. His uveitis was treated with topical steroids.

FIGURE 20-1

Acute anterior uveitis with corneal endothelial white cell aggregates (black arrow) and posterior synechiae formation (iris adhesions to the lens, white arrows). (Reproduced with permission from Paul D. Comeau.)

INTRODUCTION

Uveitis is inflammation of any component of the uveal tract: iris (anterior), ciliary body (intermediate), or choroid (posterior). Most uveitis is anterior and is also called iritis. Uveitis is caused by trauma, inflammation, or infection and the most common etiologies vary by location in the uveal tract. Patients present with vision changes and, if uveitis is anterior, eye pain, redness, tearing, and photophobia. All patients with uveitis should be referred to an ophthalmologist.

SYNONYMS

Anterior uveitis includes iritis and iridocyclitis. Iritis is when the inflammation is limited to the iris. If the ciliary body is involved too, then it is called iridocyclitis. Posterior uveitis includes choroiditis and chorioretinitis.

EPIDEMIOLOGY

  • In a large population study in Hawaii, the annual incidence of uveitis was 24.9 per 100,000 person years and the prevalence was 58 per 100,000 population.1

  • Occurs at any age, but most commonly between 25 and 64 years, and nearly equivalent between men and women.1

  • 73% of uveitis cases are anterior (also called iritis); 6% are intermediate; 21% are posterior or panuveitis.1

  • In children, juvenile rheumatoid arthritis is the most common associated systemic disease, present in over 50% of cases associated with a systemic disease and 20% of all uveitis cases in children.2

  • In the United States, noninfectious uveitis accounts for 10% of legal blindness.3

ETIOLOGY AND PATHOPHYSIOLOGY

  • Uveitis can be caused by trauma, infections, inflammation, or, rarely, neoplasms. Most likely causes differ by location.4

  • Iritis—Trauma is common (Figure 20-2). In nontraumatic cases, causes include idiopathic (50%); seronegative spondyloarthropathies, that is, ankylosing spondylitis, reactive arthritis, psoriatic arthritis, inflammatory bowel disease (20%); and juvenile idiopathic arthritis (10%). Infections are less common and include herpes, syphilis, and tuberculosis.4

  • Intermediate—Most are idiopathic4 (Figure 20-3).

  • Posterior—Toxoplasmosis is the most common, followed by idiopathic.4

  • Panuveitis (affecting all layers)—Idiopathic (22% to 45%) and sarcoidosis (14% to 28%).4 Unilateral panuveitis is often endophthalmitis (endogenous or related to ...

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