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Infectious Diseases

Providing passive immunity to the fetus, what immunoglobulin is transferred across the placenta?

a. IgA

b. IgE

c. IgG

d. IgM

What is the most common perinatal infection in the developed world?

a. Toxoplasmosis

b. Cytomegalovirus

c. Varicella-zoster virus

d. Human parvovirus B19

Which of the following statements about cytomegalovirus (CMV) is true?

a. Pregnancy increases the severity of maternal CMV infection.

b. Women who become infected with CMV during pregnancy are at the greatest risk of having an infected fetus.

c. Anti-CMV IgG antibodies render a woman immune and thus safe from recurrence, reinfection, or reactivation.

d. Women of higher income groups are more likely to be immune than women of lower socioeconomic backgrounds.

A 22-year-old G1P0 at 20 weeks’ gestation presents for consultation. Her anatomy ultrasound performed at an outside facility showed periventricular calcifications. The patient is a day-care worker with no significant medical history. She does not recall being unusually sick, but she states that she does not infrequently have a cold given her line of work. An image from the ultrasound is provided below. What is the most likely diagnosis?

Used with permission from Dr. Jodi Dashe.

a. Congenital rubella

b. Congenital varicella

c. Congenital influenza

d. Congenital cytomegalovirus

A 30-year-old G1P0 presents at 18 weeks’ gestation. Her primary physician decided to send testing for cytomegalovirus (CMV) because the patient reported a mononucleosis-like illness a month before. The testing revealed CMV IgG positive and CMV IgM positive. The patient is very concerned that her illness was primary CMV, and this baby will be affected. What is the best next step in your management?

a. Amniocentesis

b. CMV IgG avidity testing


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