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CHAPTER 20: Gestational Trophoblastic Disease

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    AMA Citation
    Gestational Trophoblastic Disease. In: Patel S, Roberts S, Rogers V, Zink A, Duryea E, Morgan J. Patel S, & Roberts S, & Rogers V, & Zink A, & Duryea E, & Morgan J(Eds.),Eds. Shivani Patel, et al.eds. Williams Obstetrics Study Guide, 25th Edition. McGraw-Hill; Accessed July 05, 2020. https://accessmedicine.mhmedical.com/content.aspx?bookid=2501&sectionid=202903260
    APA Citation
    Gestational trophoblastic disease. Patel S, Roberts S, Rogers V, Zink A, Duryea E, Morgan J. Patel S, & Roberts S, & Rogers V, & Zink A, & Duryea E, & Morgan J(Eds.),Eds. Shivani Patel, et al. (2019). Williams Obstetrics Study Guide, 25th Edition. McGraw-Hill. https://accessmedicine.mhmedical.com/content.aspx?bookid=2501&sectionid=202903260
    MLA Citation
    "Gestational Trophoblastic Disease." Williams Obstetrics Study Guide, 25th Edition Patel S, Roberts S, Rogers V, Zink A, Duryea E, Morgan J. Patel S, & Roberts S, & Rogers V, & Zink A, & Duryea E, & Morgan J(Eds.),Eds. Shivani Patel, et al. McGraw-Hill, 2019, https://accessmedicine.mhmedical.com/content.aspx?bookid=2501&sectionid=202903260.

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Gestational Trophoblastic Disease

As a group, gestational trophoblastic disease is typified by which of the following?

a. Scant cytotrophoblast

b. Perivillous fibrin deposition

c. Villous mesenchymal hyperplasia

d. Abnormal trophoblast proliferation

d Gestational Trophoblastic Disease

Measurement of which hormone is pivotal in the diagnosis, management, and surveillance of gestational trophoblastic disease?

a. Estriol

b. Alpha-fetoprotein

c. Human chorionic gonadotropin

d. All of the above

c Gestational Trophoblastic Disease

As illustrated by the microscopic differences seen here between (A) malignant invasive mole and (B) choriocarcinoma, hydatidiform moles as a group are differentiated histologically from other non-molar neoplasms by the presence of which of the following?

Used with permission from Dr. Ona Faye-Peterson.

A microscopic image of a malignant, invasive mole.
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A microscopic image of a malignant, invasive mole.

Reproduced with permission from Schorge JO: Gestational trophoblastic disease. In Hoffman BL, Schorge JO, Schaffer JI, et al (eds): Williams Gynecology, 2nd ed. New York, McGraw-Hill, 2012, Figure 37-8.

A microscopic image of choriocarcinoma and hydatidiform moles.
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A microscopic image of choriocarcinoma and hydatidiform moles.

a. Villi

b. Nuclear atypia

c. Marked angiogenesis

d. p57 immunostaining

a Gestational Trophoblastic Disease

Gestational trophoblastic neoplasia includes all of the following except which one?

a. Invasive mole

b. Choriocarcinoma

c. Partial hydatidiform mole

d. Placental site trophoblastic tumor

c Gestational Trophoblastic Disease

Ms. Audi presents to you for a second opinion. She is 19 weeks’ gestation and has a dichorionic diamnionic twin pregnancy. She tells you that her primary obstetrician told her that she was at very high risk for serious complications of pregnancy because something was wrong with one of her twins. You review the images of a magnetic resonance imaging study she had last week. A representative image is shown below with complete mole designated by asterisk, normal placenta above the mole, and the normal fetus to the left.

To help her remember the important points of your consultation, you write down ...

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