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Fetal Disorders
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Which of the following does not contribute to the low rate of alloimmunization in pregnancy?
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a. Maternal-fetal ABO incompatibility
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b. Administration of anti-D immune globulin
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c. Low prevalence of incompatible red cell antigens
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d. Consistent maternal immune response to the antigen
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A 28-year-old G2P1 presents for prenatal care at 10 weeks’ gestation. A type and screen is sent as part of her initial prenatal care labs, and it returns positive for anti-E antibodies at 1:8. What is the best first step in management?
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a. Obtain paternal antigen testing
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b. Repeat antibody titer in 4 weeks
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c. Obtain paternal antibody testing
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d. Obtain middle cerebral artery Doppler studies
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A 28-year-old G2P1 presents for prenatal care at 10 weeks’ gestation. A type and screen is sent as part of her initial prenatal care labs, and it returns positive for anti-E antibodies at 1:8. Paternal testing is not an option. The lab reports a critical titer of 1:16. What is the best next step in evaluation?
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a. Repeat antibody titer in 4 weeks
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b. Amniocentesis for fetal genotype
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c. Amniocentesis for fetal phenotype
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d. Serial middle cerebral artery Doppler studies starting at 16-18 weeks’ gestation
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A 28-year-old G2P1 presents for prenatal care at 10 weeks’ gestation. A type and screen is sent as part of her initial prenatal care labs, and it returns positive for anti-E antibodies at 1:8. Paternal testing is not an option. The lab reports a critical titer of 1:16. At what antibody titer would you recommend initiation of screening for fetal anemia with middle cerebral artery Doppler studies?
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A 36-year-old G3P2 at 28 weeks’ gestation presents as a referral for sonographic abnormalities. On ultrasound fetal pleural effusions, skin edema, and polyhydramnios are noted, as shown below. Which of ...