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Part IV: Clinical Virology
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Your patient is a 30-year-old man who has frequent episodes of herpes labialis. He asks you to tell him something about herpes simplex virus type 1 (HSV-1). Which one of the following would be the most accurate statement to make?
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(A) Acyclovir can eradicate the latent state of HSV-1 but not HSV-2.
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(B) The main site of latency by HSV-1 is the neurons in the sensory ganglia of the face.
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(C) HSV-1 is an enveloped virus that has a DNA genome and a DNA polymerase in the virion.
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(D) The lesions of primary HSV-1 infections are less extensive and less severe than the lesions of recurrent HSV-1 infections.
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(E) The laboratory diagnosis of HSV-1 infections typically involves the detection of a greater than fourfold rise in antibody titer against the virus.
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Your patient is a woman who is due to give birth next week. She asks you about the risk of her baby becoming infected with herpes simplex virus type 2 (HSV-2). Which one of the following is the most accurate response?
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(A) HSV-2 is a significant cause of congenital abnormalities.
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(B) The risk is higher if the mother has visible lesions than if she does not.
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(C) The risk is higher if the mother has IgG antibody to HSV-2 than if she has IgM antibody.
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(D) The risk is higher if the delivery occurs by cesarean section than if the delivery is performed vaginally.
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(E) The risk is higher if the mother is having an episode of recurrent disease caused by HSV-2 than if it were a primary episode.
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Regarding varicella-zoster virus (VZV), which one of the following is most accurate?
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(A) High-dose acyclovir can eliminate the latent state caused by VZV.
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(B) The principal site of latency of VZV is in the nucleus of motor neurons.
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(C) Domestic animals, such as pigs and chickens, are the main reservoir for VZV.
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(D) The vaccine against varicella contains all three serotypes of formalin-killed VZV as the immunogen.
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(E) When zoster occurs in an immunocompromised patient, acyclovir should be given to prevent disseminated infection.
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Regarding cytomegalovirus (CMV), which one of the following is most accurate?
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