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Pathogenic Fungi
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A young Phoenix woman has developed fever, cough, and after 1 month of illness has an infiltrate in the upper lobe of her right lung. A sputum specimen digested with KOH was negative but the culture grew a mold with alternating arthroconidia.
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This infection was most likely acquired by inhalation of:
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D. Asexual, arthroconidia
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E. Asexual chlamydoconidia
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A young woman who recently moved to Arizona has developed fever and malaise which have lasted for 3 weeks. Her chest radiograph is clear and her physician has diagnosed “valley fever.” Which of the following tests, using a specific preparation of the infecting agent, would raise the greatest concerns about her disease disseminating outside the lung?
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B. High levels of IgG antibody
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E. High levels of capsular antigen
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A young woman has developed fever and diffuse pulmonary infiltrates 1 week after undergoing a bone marrow transplant. She is on immunosuppressive therapy. Material collected in a bronchoalveolar lavage has demonstrated septate branching hyphae and she was placed on amphotericin B. The target of this therapy is:
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A. Cell wall mannoprotein
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D. Mitotic spindle fibers
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You are asked to evaluate the antifungal therapy of a patient with an enlarged liver and spleen. The laboratory finding shows that culture of a lymph node biopsy yielded a small (4 mm) yeast at 35°C, which at 25°C grew as a mold with tuberculate macroconidia. The patient most probably acquired this infection in:
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A. Semitropical regions of North and South America
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B. Ohio and Mississippi River valleys
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C. Arid deserts of America and Africa
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D. Lower Sonoran life zone
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A 75-year-old man presents with headache and confusion. He has a low grade fever and 10 lymphocytes in his CSF. Cultures ...