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Antiviral drugs are used for a variety of infections, including herpesvirus, hepatitis B (HBV) and C (HCV), and influenza. Antiviral drugs that target human immunodeficiency virus (HIV) are referred to as antiretrovirals. A wide variety of antiretroviral agents from different mechanistic classes are now available (Table II–12). Antiretrovirals are typically given in combination to treat HIV infection. New multiple-drug combined formulations have been developed to decrease the number of pills to take per day and increase adherence to treatment regimens. Some antiretrovirals are also active against HBV. The management of HCV has been revolutionized by the development of new anti-HCV agents, usually given in combination.


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