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Chapter 1. Genetics: Unity and Diversity

In reference to a "genome"

A. the term exclusively refers to DNA that is found in the nucleus.

B. it is the genetic information needed to code for the development of an individual.

C. it can be defined in terms of the protein content of an individual's cells.

D. the genome size and the amount of information coded typically have a 1:1 correlation.

E. is the small person who lives underground and hoards treasure.

B is the correct answer. The other answers are incorrect because:

  • A. The genome includes DNA outside of the nucleus, such as in the mitochondria.

  • C. It is the DNA content, not the protein content, of a cell that is its genome.

  • D. The correlation of genomic size and the amount of information encoded has a poor correlation especially in more complex organisms.

  • E. You know why.

The Human Genome Project

A. gave a best estimate of 100,000 as the total number of functioning human genes.

B. has identified a much greater diversity of the genetics among different species than expected.

C. is completed and has identified the sequence of all human genetic conditions.

D. made a concerted effort to address ethical and social issues associated with the information generated.

E. in general has kept the information it generated locked up and away from public access.

D is the correct answer. The other answers are incorrect because:

  • A. The current best estimate for humans is 22,000 functioning genes.

  • B. One of the many surprises has been the marked homology of genes among species.

  • C. Although the overall sequence has been identified, the actual assignment of sequences to specific genes (and diseases) is nowhere close to complete.

  • E. The information from the genome project has been made widely available to the public.

Personalized medicine

A. is likely to drive up medical costs if implemented.

B. is a theoretical type of practice that may have future applications in clinical practice.

C. should have little impact on the diagnostic process.

D. may be used to direct therapy or identify individual susceptibilities.

E. should have application in the primary prevention of disorders.

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