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Chapter 1. Genetics: Unity and Diversity

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In reference to a "genome"

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A. the term exclusively refers to DNA that is found in the nucleus.

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B. it is the genetic information needed to code for the development of an individual.

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C. it can be defined in terms of the protein content of an individual's cells.

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D. the genome size and the amount of information coded typically have a 1:1 correlation.

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E. is the small person who lives underground and hoards treasure.

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B is the correct answer. The other answers are incorrect because:

  • A. The genome includes DNA outside of the nucleus, such as in the mitochondria.

  • C. It is the DNA content, not the protein content, of a cell that is its genome.

  • D. The correlation of genomic size and the amount of information encoded has a poor correlation especially in more complex organisms.

  • E. You know why.

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The Human Genome Project

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A. gave a best estimate of 100,000 as the total number of functioning human genes.

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B. has identified a much greater diversity of the genetics among different species than expected.

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C. is completed and has identified the sequence of all human genetic conditions.

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D. made a concerted effort to address ethical and social issues associated with the information generated.

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E. in general has kept the information it generated locked up and away from public access.

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D is the correct answer. The other answers are incorrect because:

  • A. The current best estimate for humans is 22,000 functioning genes.

  • B. One of the many surprises has been the marked homology of genes among species.

  • C. Although the overall sequence has been identified, the actual assignment of sequences to specific genes (and diseases) is nowhere close to complete.

  • E. The information from the genome project has been made widely available to the public.

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Personalized medicine

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A. is likely to drive up medical costs if implemented.

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B. is a theoretical type of practice that may have future applications in clinical practice.

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C. should have little impact on the diagnostic process.

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D. may be used to direct therapy or identify individual susceptibilities.

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E. should have application in the primary prevention of disorders.

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