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Appendix B

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Table B–1.Classes of diurectics
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Table B–1. Classes of diurectics
Class Mechanism Major site affected

Carbonic anhydrase inhibitors

Inhibit secretion of hydrogen ions, which reduces reabsorption of bicarbonate and sodium

Proximal tubule

Loop diuretics

Inhibit Na-K-2Cl symporter in luminal membrane

Thick ascending limb of Henle loop

Thiazides

Inhibit Na-Cl symporter in luminal membrane

Distal convoluted tubule

Potassium-sparing diuretics

Inhibit action of aldosterone

Block sodium channels

Cortical collecting tubule

Cortical collecting tubule

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