This volume is dedicated to William Francis (“Fran”) Ganong, renowned physiologist and neuroendocrinologist. From the first edition in 1963, until the 22nd, he was the sole author of Review of Medical Physiology. At the time of his death in 2007, it was one of the most widely used physiology textbook in the world, and it retains an intensely loyal following. His dedication to the volume was legendary, and he was well known for always carrying index cards at his long-term institution, the University of California, San Francisco, where he was a faculty member for almost 50 years and chaired the Department of Physiology from 1970 to 1987. The cards would be used to gather facts from colleagues and visiting speakers, and the facts would be accumulated to inform the next edition of his text—remarkably, completed without fail every 2 years. It is fitting that this new derivative of his life-long work will serve to educate new generations of medical and other health professional students.