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A number of immunologically mediated skin diseases and immunologically mediated systemic disorders with cutaneous manifestations are now recognized as distinct entities with consistent clinical, histologic, and immunopathologic findings. Clinically, these disorders are characterized by morbidity (pain, pruritus, disfigurement) and, in some instances, result in death (largely due to loss of epidermal barrier function and/or secondary infection). The major features of the more common immunologically mediated skin diseases are summarized in this chapter (Table 55-1), as are autoimmune systemic disorders with cutaneous manifestations.

TABLE 55-1Immunologically Mediated Blistering Diseases



Pemphigus refers to a group of autoantibody-mediated ...

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