Updated to new reference on impact of heterozygous mutations of the PRL receptor.
The anterior pituitary often is referred to as the “master gland” because, together with the hypothalamus, it orchestrates the complex regulatory functions of many other endocrine glands. The anterior pituitary gland produces six major hormones: (1) prolactin (PRL), (2) growth hormone (GH), (3) adrenocorticotropic hormone (ACTH), (4) luteinizing hormone (LH), (5) follicle-stimulating hormone (FSH), and (6) thyroid-stimulating hormone (TSH) (Table 371-1). Pituitary hormones are secreted in a pulsatile manner, reflecting regulation by an array of specific hypothalamic releasing factors. Each of these pituitary hormones elicits specific trophic responses in peripheral target tissues. The hormonal products of those peripheral glands, in turn, exert feedback control at the level of the hypothalamus and pituitary to modulate pituitary function (Fig. 371-1). Pituitary tumors cause characteristic hormone excess syndromes. Hormone deficiency may be inherited or acquired. Fortunately, there are efficacious treatments for many pituitary hormone excess and deficiency syndromes. Nonetheless, these diagnoses are often elusive; this emphasizes the importance of recognizing subtle clinical manifestations and performing the correct laboratory diagnostic tests. For discussion of disorders of the posterior pituitary, or neurohypophysis, see Chap. 374.
TABLE 371-1Anterior Pituitary Hormone Expression and Regulation ||Download (.pdf) TABLE 371-1 Anterior Pituitary Hormone Expression and Regulation
|CELL ||CORTICOTROPE ||SOMATOTROPE ||LACTOTROPE ||THYROTROPE ||GONADOTROPE |
|Tissue-specific transcription factor ||T-Pit ||Prop-1, Pit-1 ||Prop-1, Pit-1 ||Prop-1, Pit-1, TEF ||SF-1, DAX-1 |
|Fetal appearance ||6 weeks ||8 weeks ||12 weeks ||12 weeks ||12 weeks |
|Hormone ||POMC ||GH ||PRL ||TSH ||FSH, LH |
|Protein ||Polypeptide ||Polypeptide ||Polypeptide ||Glycoprotein α, β subunits ||Glycoprotein α, β subunits |
|Amino acids ||266 (ACTH 1–39) ||191 ||198 ||211 ||210, 204 |
|Stimulators ||CRH, AVP, gp-130 cytokines ||GHRH, ghrelin ||Estrogen, TRH, VIP ||TRH ||GnRH, activins, estrogen |
|Inhibitors ||Glucocorticoids ||Somatostatin, IGF-I ||Dopamine ||T3, T4, dopamine, somatostatin, glucocorticoids ||Sex steroids, inhibin |
|Target gland ||Adrenal ||Liver, bone, other tissues ||Breast, other tissues ||Thyroid ||Ovary, testis |
|Trophic effect ||Steroid production ||IGF-I production, growth induction, insulin antagonism ||Milk production ||T4 synthesis and secretion ||Sex steroid production, follicle growth, germ cell maturation |
|Normal range ||ACTH, 4–22 pg/L ||<0.5 μg/La ||M <15 μg/L; F <20 μg/L ||0.1–5 mU/L ||M, 5–20 IU/L; F (basal), 5–20 IU/L |
Diagram of pituitary axes. Hypothalamic hormones regulate anterior pituitary trophic hormones that in turn determine target gland secretion. Peripheral hormones feed back to regulate hypothalamic and pituitary hormones. For abbreviations, see text.
The pituitary gland weighs ~600 mg and is ...