| Animal bite (prophylaxis or early infection)a | Amoxicillin/clavulanate, 875/125 mg PO bid | Doxycycline, 100 mg PO bid | 27 |
| Animal bitea (established infection) | Ampicillin/sulbactam, 1.5–3 g IV q6h | Clindamycin, 600–900 mg IV q8h, plus Ciprofloxacin, 400 mg IV q12h, or cefoxitin, 2 g IV q6h | 27 |
| Bacillary angiomatosis | Erythromycin, 500 mg PO qid | Doxycycline, 100 mg PO bid | 91 |
| Herpes simplex (primary genital) | Acyclovir, 400 mg PO tid for 10 days | Famciclovir, 250 mg PO tid for 5–10 days, | 99 |
| | | or | |
| | | Valacyclovir, 1000 mg PO bid for 10 days | |
| Herpes zoster (immunocompetent host >50 years of age) | Acyclovir, 800 mg PO 5 times daily for 7–10 days | Famciclovir, 500 mg PO tid for 7–10 days, or Valacyclovir, 1000 mg PO tid for 7 days | 99 |
| Cellulitis (staphylococcal or streptococcalb,c) | Nafcillin or oxacillin, 2 g IV q4–6h | Cefazolin, 1–2 g q8h, or Ampicillin/sulbactam, 1.5–3 g IV q6h, or Erythromycin, 0.5–1 g IV q6h, or Clindamycin, 600–900 mg IV q8h | 86, 87 |
| MRSA skin infectiond | Vancomycin, 1 g IV q12h | Linezolid, 600 mg IV q12h | 86 |
| Necrotizing fasciitis (group A streptococcalb) | Clindamycin, 600–900 mg IV q6–8h, plus Penicillin G, 4 million units IV q4h | Clindamycin, 600–900 mg IV q6–8h, plus Cephalosporin (first- or second-generation) | 87 |
| Necrotizing fasciitis (mixed aerobes and anaerobes) | Ampicillin, 2 g IV q4h, plus Clindamycin, 600–900 mg IV q6–8h, plus Ciprofloxacin, 400 mg IV q6–8h | Vancomycin, 1 g IV q6h, plus Metronidazole, 500 mg IV q6h, plus Ciprofloxacin, 400 mg IV q6–8h | 92 |
| Gas gangrene | Clindamycin, 600–900 mg IV q6–8h, | Clindamycin, 600–900 mg IV q6–8h, | 92 |
| | plus | plus | |
| | Penicillin G, 4 million units IV q4–6h | Cefoxitin, 2 g IV q6h | |