Skin and soft tissue infections are some of the most common infectious diagnoses and result in hundreds of thousands of medical office and emergency room visits each year. These infections often occur following a break in normal skin integrity from either trauma or skin disease (e.g., atopic dermatitis). The vast majority of these infections are caused by Staphylococcus aureus and Streptococcus pyogenes (Table 77–1). Hematogenous seeding of organisms into the skin can occur but is uncommon. Normal histology of the skin can be seen in Figure 77–1.
Layers of the skin and subcutaneous tissue. Note sebaceous glands (purple coils) and hair follicles with protruding hair. (Reproduced with permission from Mescher AL. Chapter 18. Skin. In: Mescher AL. eds. Junqueira’s Basic Histology: Text & Atlas, 13e. New York, NY: McGraw-Hill; 2013.)
Table 77–1Skin and Soft Tissue Infections: Appearance of Lesions, Skin Layers Involved, Common Pathogens, and Treatment Modalities |Favorite Table|Download (.pdf) Table 77–1 Skin and Soft Tissue Infections: Appearance of Lesions, Skin Layers Involved, Common Pathogens, and Treatment Modalities
|Type of Infection ||Appearance of Lesion ||Description of Lesion ||Layer of Skin Involved ||Common Pathogens ||Treatment |
|Impetigo || ||Vesicles with honey-colored crust, often on the face of a child ||Epidermis ||Staphylococcus aureus, Streptococcus pyogenes ||Few lesions: topical antibiotics (e.g., mupirocin); numerous lesions: systemic therapy (e.g., cephalexin, clindamycin) |
|Erysipelas || |
|Erythematous, very painful lesion with sharply demarcated, raised, regular border ||Superficial dermis ||S. pyogenes, Streptococcus agalactiae > S. aureus ||Systemic antibiotics (e.g., cephalexin or cefazolin) |
|Cellulitis || ||Erythematous diffuse, flat lesion with irregular border ||Deep dermis ||S. pyogenes, S. agalactiae > S. aureus ||Systemic antibiotics (e.g., cephalexin or cefazolin.) |
|Folliculitis || |
|Localized, inflamed papules containing a small amount of pus ||Hair follicle ||S. aureus, Pseudomonas aeruginosa (associated with hot tubs) ||Antibiotics often not needed; warm, moist compresses are useful |
|Skin abscess (also known as a boil, furuncle, carbuncle) || ||Raised, tender, inflamed nodule with central region of purulence; the area of pus initially is firm but then progresses to fluctuance (becomes movable) ||Deep dermis ||S. aureus ||Incision and drainage is mainstay of therapy; antibiotics directed against S. aureus in select cases |
|Necrotizing soft tissue infections (necrotizing fasciitis) || |
|Very painful area of inflammation with rapid progression to necrosis, bullae, purpura, anesthesia, and systemic toxicity ||Fascia and muscle; local blood vessels and nerves also involved || |
1. Monomicrobial form: S. pyogenes, Clostridium perfringens, Vibrio vulnificus;
2. Polymicrobial form: enteric gram-negative rods plus anaerobes
|Surgical debridement is critical in addition to broad-spectrum systemic antibiotics |
Impetigo is an infection of the epidermal layer of skin.
There are two modes of acquisition of impetigo, primary infection that occurs in otherwise normal skin or secondary impetigo, which occurs following a break in normal skin integrity. ...