VI.C: Histiocytic and Myeloid Dendritic Leukemias

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VI.C.001

Acute myeloid-dendritic cell leukemia. (A) Stained film of cells from case of myeloid-dendritic cell leukemia. Note villous surface and hypogranular cytoplasm. Cells range from blasts to more mature appearing forms. (B). Low power phase contrast microscopy of wet reparation of a patient’s blood cells with branching and elongated cells. (C) Patients cells after incubation with cytokines.

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VI.C.002

Langerhans cell histiocytosis. Transmission electron micrograph of a pathological Langerhans cell in a bone lesion. The cell contains typical Langerhans cell inclusions, called Birbeck bodies (arrow). The Birbeck bodies have a characteristic racquet shape and are found only in Langerhans cells, making them a specific diagnostic marker.

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VI.C.003

Langerhans cell histiocytosis. (A) H&E morphologic appearance with sheets of Langerhans cell histiocytes showing nuclear grooves. A few eosinophils are noted. (B) Langerhans cell histiocytes react on immunohistochemical staining for CD1a and (C) for the beta subunit of the protein S100. Both markers are used to identify the cells in this disorder.