Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ V.G.001 Alcohol Poisoning ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) V.G.001 Alcohol poisoning. Marrow cells of a patient with chronic and acute alcoholism. Note dyserythropoiesis. Small erythroblasts with scant cytoplasm. Large orthochromatic erythroblast with lobulated nucleus. Three large erythroblasts (one proerythroblast and two basophilic erythroblasts) with vacuoles characteristic (but not specific for) of acute alcoholism. The vacuoles usually occur in early erythroid cells as seen here and very occasionally in myeloid cells. They may be observed after abstinence for about 3 to 14 days, suggesting the vacuoles persist that long despite cell division and maturation. The vacuoles often appear to overlie the nucleus as well as the cytoplasm, but in electron micrographic studies, they form from endocytotic vesicles and are localized only to the cytoplasm. +++ V.G.002 Arsenic Poisoning ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) V.G.002 Arsenic poisoning. Marrow cells of patient with severe arsenic intoxication. Note severe dyserythropoiesis with megaloblastic features. Erythroblasts are mildly increased in size with bizarre nuclear abnormalities including multilobulated nuclei, open chromatin pattern simulating megaloblastic appearance. Note two very coarsely stippled erythroblasts. +++ V.G.003 Arsenic Intoxication ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) V.G.003 Arsenic Intoxication. Marrow Films. (A)Erythroblasts with nuclear fragmentation and nuclear remnants in cytoplasm. (B)Large erythroblasts with nuclear lobulation and with chromatin patterns similar to that seen in megaloblastic anemia. The dyserythropoiesis of arsenic poisoning mimics that seen in megaloblastic anemia and has morphologic features similar to erythropoiesis in myelodysplastic syndrome. +++ V.G.004 Congenital Dyserythropoietic Anemia, Type I ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) V.G.004 Congenital dyserythropoietic anemia, type I. Note nuclear bridging in erythroblasts. Dyserythropoietic features also include wide variation in erythroblast size. Note three very small cells in upper center of field. +++ V.G.005 Congenital Dyserythropoietic Anemia, Type I ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) V.G.005 Congenital dyserythropoietic anemia, type I. Note erythroblast with double nucleus. Large (giant) erythroblasts. +++ V.G.006 Congenital Dyserythropoietic Anemia, Type II ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) V.G.006 Congenital dyserythropoietic anemia, type II. Hereditary Erythroblastic Multinuclearity associated with a Positive Acidified Serum test (HEMPAS). Multinucleated erythroblasts. Note binucleate erythroblast and one cell with five nuclei. This variant of congenital dyserythropoietic anemia has erythroblasts with two to seven nuclei. +++ V.G.007 Congenital Dyserythropoietic Anemia, Type II ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) V.G.007 Congenital dyserythropoietic anemia, Type II. Marrow films. (A and B) Note large and multinucleated erythroblasts characteristic of this disorder. (A) Four nuclei in erythroblast. (B) Two and six nuclei in erythroblasts. In later cell, a seventh nuclear remnant is present. +++ V.G.008 Congenital Dyserythropietic ... Your MyAccess profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Username? Forgot Password? Sign in via OpenAthens Sign in via Shibboleth