Ventilatory disorders, reflected by abnormalities in Paco2, include alterations in CO2 production, minute ventilation, or respiratory system dead space. Many diseases can cause acute elevations in CO2 production; chronic ventilatory disorders relate to inappropriate minute ventilation or dead space fraction.
Chronic hypoventilation can result from parenchymal lung diseases, chest wall abnormalities (e.g., severe kyphoscoliosis), sleep-disordered breathing, neuromuscular diseases, and abnormal respiratory drive. Obesity-hypoventilation syndrome includes body mass index ≥30 kg/m2; sleep-disordered breathing (typically obstructive sleep apnea); Paco2 >45 mmHg; and Pao2 <70 mmHg. Central hypoventilation syndrome is a rare disorder that includes a failure of the normal respiratory response to hypoxemia and/or hypercapnia.
Key symptoms of hypoventilation can include exertional dyspnea, orthopnea, daytime somnolence, morning headache, and anxiety. Parenchymal lung diseases, such as chronic obstructive pulmonary disease and interstitial lung disease, often include dyspnea and cough. Sleep-disordered breathing includes daytime somnolence, snoring, and fragmented sleep. Orthopnea is common in neuromuscular disorders, although weakness of the extremities or other muscle groups often precedes respiratory system muscular weakness. Hypoventilation related to neuromuscular and chest wall disorders progresses from asymptomatic to nocturnal hypoventilation to daytime hypercapnia. Chronic narcotic use and hypothyroidism can lead to reduced respiratory drive.
Physical examination, chest radiographic studies (chest x-ray and possibly chest CT), and pulmonary function tests reveal most lung parenchymal and chest wall causes of hypoventilation. Measurement of maximal inspiratory and expiratory pressures can assess respiratory muscle strength. Polysomnography to assess for obstructive sleep apnea should also be considered. When pts have hypercapnia with normal pulmonary function, normal respiratory muscle strength, and normal alveolar-arterial Po2 difference, respiratory drive abnormalities may be present, which can be revealed by polysomnography. Laboratory findings include increased Paco2 and often reduced Pao2 as well. Compensatory increases in plasma bicarbonate levels and normal pH are seen in chronic hypoventilation. Eventually, pulmonary hypertension and cor pulmonale can develop. In central hypoventilation syndrome, hypercapnia worsens substantially during sleep.
In all forms of hypoventilation, supplemental oxygen should be given to correct hypoxemia. Obesity-hypoventilation is treated with weight reduction and continuous positive airway pressure (CPAP) during sleep. Some pts may require bilevel positive airway pressure (BiPAP).
Noninvasive positive pressure ventilation during sleep can provide ventilatory support and treat sleep apnea associated with neuromuscular disorders, chest wall disorders, and central hypoventilation. With progressive neuromuscular disorders, full-time mechanical ventilatory support is often required.
Pts with respiratory drive disorders may benefit from phrenic nerve pacing
Hyperventilation is caused by ventilation in excess of requirements based on CO2 production, leading to a reduced Paco2. Although anxiety can contribute to the initiation and progression of hyperventilation, hyperventilation is not always related to anxiety. Hyperventilation can precede systemic illnesses such as diabetic ketoacidosis.