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NOTE: Dr. Fauci's work as editor and author was performed outside the scope of his employment as a U.S. government employee. This work represents his personal and professional views and not necessarily those of the U.S. government.

HARRISON's PRINCIPLES OF INTERNAL MEDICINE Eighteenth Edition MANUAL OF MEDICINE Copyright © 2013, 2009, 2005, 2002, 1998, 1995, 1991, 1988 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval system, without the prior written consent of the author.

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ISBN 978-0-07-174519-2

MHID 0-07-174519-X

This book was set in Minion Pro by Cenveo Publisher Services. The editors were James F. Shanahan and Kim J. Davis. The production supervisor was Catherine H. Saggese; project management was provided by Vastavikta Sharma, Cenveo Publisher Services. The designer was Alan Barnett; the cover designer was Anthony Landi. RR Donnelly was printer and binder.

Library of Congress Cataloging-in-Publication Data

International Edition ISBN 978-0-07-179290-5; MHID 0-07-179290-2.

Copyright © 2013. Exclusive rights by The McGraw-Hill Companies, Inc., for manufacture and export. This book cannot be re-exported from the country to which it is consigned by McGraw-Hill. The International Edition is not available in North America.

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