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What percentage of individuals will experience a disease with a genetic component during the course of their lifetime?

a. 10%

b. 33%

c. 66%

d. 85%

When correctly reporting a karyotype, where should the sex chromosomes be listed?

a. First, before the total number of chromosomes

b. Second, after the total number of chromosomes

c. Last, after any description of structural abnormalities

d. None of the above

Which of the following karyotypes accurately describes a female with a deletion on the long arm of chromosome 17 at band q3?

a. 46,XY,del(17)(q3)

b. 46,del(17)(q3)

c. 46,XX,del(17)(q3)

d. XX,46,del(17)(q3)

What is the most common cause of the abnormality depicted in the karyotype below?

Reproduced with permission from Cunningham FG, Leveno KJ, Bloom SL, et al (eds): Genetics. In Williams Obstetrics, 24th ed. New York, McGraw-Hill, 2014, Figure 13-3.

a. Dispermy

b. Mitotic nondisjunction

c. Meiotic nondisjunction

d. Unbalanced translocation

Trisomy of which of the following autosomal chromosomes is LEAST likely to result in a term pregnancy?

a. 8

b. 13

c. 18

d. 21

Which of the following generalizations is true regarding the reproductive capacity of adults with Down syndrome?

a. Both males and females are sterile.

b. Both males and females are fertile.

c. Males are fertile, and females are sterile.

d. Males are sterile, and females are fertile.


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