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eFigure 15–3. Hemoglobin H disease, on peripheral blood smear. Note strikingly small RBCs (microcytosis), with pallor and thin rim of hemoglobin (hypochromia), and abnormally shaped RBCs (poikilocytes), including target cells. (Reproduced, with permission, from Lichtman MA, Shafer MS, Felgar RE, Wang N. Lichtman's Atlas of Hematology. McGraw-Hill, 2016.) A micrograph of the blood smear from a case of Hemoglobin H disease reveals small, abnormally shaped red blood cells with pale centers and pink borders. Some of the cells have a bull's eye appearance with a red border and a red center, and some are elongated.

Current Medical Diagnosis & Treatment 2025 > The Thalassemias

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eFigure 15–13. Sickle cell disease, peripheral blood smear. In this patient with hemoglobin SS disease, there are two characteristic cells (arrows). One is the classic crescent shaped cell pathognomonic of sickle cell disease. The other is an elliptical RBC with condensation of hemoglobin leaving a paler outer rim of cytoplasm, also characteristic of hemoglobin SS. Also present in the center of the smear are two target cells. (Reproduced, with permission, from Lichtman MA, Shafer MS, Felgar RE, Wang N. Lichtman's Atlas of Hematology. McGraw-Hill, 2016.) A micrograph of the blood film from a case of sickle cell disease. The image reveals crescent shaped cells, indicated by arrows. There are also elongated cells, and target cells with dark borders, internal pallor, and dark centers.

Current Medical Diagnosis & Treatment 2025 > Sickle Cell Anemia & Related Syndromes

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eFigure 15–15. Hemoglobin CC disease, peripheral blood smear. In this patient who is post-splenectomy, it is easy to note characteristic elliptical crystal-like precipitates of hemoglobin C as well as markedly increased frequency of target cells. The RBC inclusion in the upper right corner is a Howell Jolly body, indicative of the asplenic state. (Reproduced, with permission, from Lichtman MA, Shafer MS, Felgar RE, Wang N. Lichtman's Atlas of Hematology. McGraw-Hill, 2016.) A micrograph of the blood film from a case of Hemoglobin C C disease. The reveals numerous target cells, which have dark borders, pallor, and dark centers. There are dark elliptical precipitates, and a tiny, dark spherical inclusion in the top right of the field.

Current Medical Diagnosis & Treatment 2025 > Hemoglobin C Disorders

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