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Pituitary and Hypothalamic Disorders

Joseph Mort
  1. Understand the hypothalamic-pituitary axis, the hormones secreted from these glands, and the regulatory mechanisms that control hormone secretion.
  2. Identify the symptoms of hypopituitarism (affecting individual hormones and panhypopituitarism) and list possible causes of these disorders.
  3. Identify the symptoms of a pituitary mass lesion and list pathologies that cause mass lesions in the sella turcica.
  4. Recognize the typical presentation associated with overexpression of each of the following pituitary hormones (ACTH, growth hormone, TSH, LH/FSH, prolactin). 
  5. Understand how hormone levels at various levels of the hypothalamic-pituitary axis can be used to diagnose pathologies of over or under production (i.e. levels of CRH, ACTH, cortisol and the dexamethasone suppression test).
  6. Explain how dysfunction in secretion of antidiuretic hormone from the posterior pituitary leads to diabetes insipidus and syndrome of inappropriate antidiuretic hormone.
AccessMedicine > Huppert’s Notes: Pathophysiology and Clinical Pearls for Internal Medicine > Anatomy and Physiology in Endocrinology > PITUITARY
AccessMedicine > Harrison's Principles of Internal Medicine, 21e > Hypopituitarism
Case File
AccessMedicine > Case Files: Internal Medicine 6e > Case 49 > Adrenal Insufficiency
Case File
AccessMedicine > Pathophysiology of Disease Cases > Case 103 > Hypopituitarism
Case File
AccessMedicine > Graber and Wilbur’s Family Medicine Examination and Board Review, 5th Edition > Endocrinology Case 10.08 > Endocrinology Case 10.08
AccessMedicine > The Infographic Guide to Medicine > Endocrinology > Pituitary Neoplasm
AccessMedicine > The Infographic Guide to Medicine > Endocrinology > Hypopituitarism


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