RT Book, Section
A1 Ryan, Daniel H.
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121088393
T1 Examination of the Marrow
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK accessmedicine.mhmedical.com/content.aspx?aid=1121088393
RD 2024/04/19
AB SUMMARYMicroscopic  examination  of  the  marrow  is  a  mainstay  of  hematologic  diagnosis.  Even  with  the  advent  of  specialized  biochemical  and  molecular  assays  that  capitalize  on  advances  in  our  understanding  of  the  cell  biology  of  hematopoiesis,  the  primary  diagnosis  of  hematologic  malignancies  and  many  nonneoplastic  hematologic  disorders  relies  upon  examination  of  the  cells  in  the  marrow.  An  aspirate  and  biopsy  of  the  marrow  can  be  obtained  with  minimal  risk  and  only  minor  discomfort  and  are  quickly  and  easily  processed  for  examination.  The  marrow  should  be  examined  when  the  clinical  history,  blood  cell  counts,  blood  film,  or  laboratory  test  results  suggest  the  possibility  of  a  primary  or  secondary  hematologic  disorder  for  which  morphologic  analysis  or  special  studies  of  the  marrow  would  aid  in  the  diagnosis.  Leukopenia  or  thrombocytopenia  may  require  a  marrow  examination  for  diagnosis.  Nonhemolytic  anemia  that  is  not  readily  diagnosed  by  blood  cell  examination  and  supporting  laboratory  tests  often  requires  a  marrow  examination.  Abnormal  cells  in  the  blood,  such  as  nucleated  red  cells,  white  cell  precursors,  abnormal  lymphocytes  not  explained  by  concurrent  infection,  and  blast  cells,  usually  require  a  marrow  examination.  In  addition  to  determining  the  cellularity  and  morphology  of  precursor  cells,  or  infiltration  by  nonhematopoietic  cells,  the  study  provides  marrow  cells  for  immunophenotyping,  cytogenetic,  molecular  and  genomic  studies,  culture  of  infectious  organisms,  and  storage  of  marrow  cells  for  further  analysis.