RT Book, Section A1 Hernandez, German T. A1 Rodriguez, Rudolph A. A2 LaDou, Joseph A2 Harrison, Robert J. SR Print(0) ID 1104104391 T1 Renal Toxicology T2 CURRENT Diagnosis & Treatment: Occupational & Environmental Medicine, 5e YR 2013 FD 2013 PB McGraw-Hill Education PP New York, NY SN 9780071808156 LK accessmedicine.mhmedical.com/content.aspx?aid=1104104391 RD 2024/04/24 AB In the United States, 594,374 patients were treated for end-stage renal disease (ESRD) in the year 2010 at a yearly cost of well over $47 billion. Both the number of patients and the associated costs continue to grow annually. The etiology of the kidney injury in a significant percentage of these patients is never fully elucidated, and the diagnosis of renal disease of occupational origin is rarely considered. The true incidence of chronic kidney disease secondary to occupational and environmental exposures in the United States is unknown. However, these exposures represent potentially preventable causes of chronic kidney disease. Even if occupational and environmental exposures account for only a small percentage of the causes of ESRD in the United States, the significant morbidity, mortality, and costs associated with renal replacement therapy potentially could be prevented.