RT Book, Section
A1 Gala, Manish
A1 Chung, Daniel C.
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102700498
T1 Cancers of the Small and Large Intestine
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessmedicine.mhmedical.com/content.aspx?aid=1102700498
RD 2024/04/19
AB Disease  summary:Colorectal  cancer  remains  the  second  leading  cause  of  cancer  deaths  in  the  United  States,  with  an  estimated  143,000  new  diagnoses  anticipated  in  2012.  The  lifetime  risk  of  any  individual  developing  colon  cancer  is  5.1%.  Often,  the  disease  has  no  presenting  symptoms,  but  can  manifest  through  changes  in  bowel  habits  or  appetite,  vague  abdominal  pain,  overt  bleeding,  occult  blood  loss,  iron  deficiency  anemia,  weight  loss,  or  obstructive  bowel  symptoms.  A  significant  number  of  afflicted  individuals  demonstrate  a  family  history  of  colon  cancer.  Moreover,  a  small  subset  of  these  individuals  will  present  with  features  of  an  established  familial  cancer  syndrome.  Careful  integration  of  the  family  and  personal  history,  physical  examination  findings,  and  endoscopic  findings  play  a  critical  role  in  recognition  and  management  of  these  high-risk  individuals.  Small  bowel  cancers  remain  rare,  and  account  for  less  than  0.5%  of  all  new  cancers  diagnosed.  Malignancies  of  the  small  bowel  include  adenocarcinoma,  lymphomas,  carcinoids,  and  mesenchymal  tumors.  On  occasion,  cancers  of  the  small  bowel  may  also  represent  as  a  manifestation  of  a  familial  cancer  syndrome.