RT Book, Section
A1 Sager, Solomon
A1 Dolinsky, Jill S.
A1 Hershberger, Ray E.
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102699424
T1 Dilated Cardiomyopathy
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessmedicine.mhmedical.com/content.aspx?aid=1102699424
RD 2024/04/23
AB Disease  summary:Dilated  cardiomyopathy  (DCM)  is  characterized  by  left  ventricular  (LV)  enlargement  and  systolic  dysfunction.The  prevalence  of  DCM  is  1  in  2700,  however,  this  is  undoubtedly  an  underestimate.Histologic  findings  include  myocyte  hypertrophy,  myocyte  loss,  and  interstitial  fibrosis.Approximately  35%  of  DCM  cases  are  deemed  idiopathic  dilated  cardiomyopathy  (IDC)  after  detectable  causes  have  been  excluded  (Fig.  24-1).20%  to  50%  of  IDC  may  be  found  in  one  or  more  family  members,  and  if  so,  is  termed  familial  dilated  cardiomyopathy  (FDC).  Of  these  cases,  approximately  20%  to  25%  have  identifiable  genetic  mutations  correlating  with  disease  phenotype.