RT Book, Section
A1 Seton, Margaret
A2 Imboden, John B.
A2 Hellmann, David B.
A2 Stone, John H.
SR Print(0)
ID 57275476
T1 Chapter 60. Paget Disease of Bone
T2 CURRENT Diagnosis & Treatment: Rheumatology, 3e
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-163805-0
LK accessmedicine.mhmedical.com/content.aspx?aid=57275476
RD 2024/04/19
AB Paget  disease  of  bone  (PDB)  is  a  remarkable  disorder  of  aging  bone.  It  was  first  described  by  Sir  James  Paget  in  1877,  in  his  paper  entitled  “On  a  Form  of  Chronic  Inflammation  of  Bones  (Osteitis  Deformans).”  In  this  sentinel  paper,  Paget  catalogues  the  progressive  deformity  of  bone  that  occurs  over  26  years  in  an  individual  man,  detailing  the  enlargement  of  his  head,  the  settling  of  the  skull  over  the  spine,  the  evolving  rigidity  of  the  spine  and  bowing  of  the  lower  limbs.  “The  shape  and  habitual  posture  of  the  patient  were  thus  made  strange  and  peculiar.”  Paget  attributed  these  skeletal  changes  to  chronic  inflammation  of  the  affected  bones,  and  called  the  disease  osteitis  deformans,  writing  “a  better  name  may  be  given  when  more  is  known  of  it.”