RT Book, Section A1 Dall'Era, Maria A2 Imboden, John B. A2 Hellmann, David B. A2 Stone, John H. SR Print(0) ID 57272268 T1 Chapter 21. Systemic Lupus Erythematosus T2 CURRENT Diagnosis & Treatment: Rheumatology, 3e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-163805-0 LK accessmedicine.mhmedical.com/content.aspx?aid=57272268 RD 2024/04/19 AB Predilection for females of childbearing age.Multisystem disease, often with a relapsing-remitting course.Photosensitive rash, polyarthritis, serositis, and fatigue are common manifestations of disease flares.Renal disease and central nervous system involvement are important causes of morbidity.Presence of antinuclear antibodies.Certain autoantibodies (anti-dsDNA and anti-Sm) have great specificity for the diagnosis of SLE, but lack sensitivity.Hypocomplementemia may occur during flares.