RT Book, Section
A1 Maddrey, Willis C.
A2 Greenberger, Norton J.
A2 Blumberg, Richard S.
A2 Burakoff, Robert
SR Print(0)
ID 55961587
T1 Chapter 48. Drug-Induced Liver Disease
T2 CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-176848-1
LK accessmedicine.mhmedical.com/content.aspx?aid=55961587
RD 2024/04/19
AB A  remarkable  array  of  therapeutic  drugs  has  been  shown  to  cause  hepatic  injuries  of  many  types.  There  are  no  specific  diagnostic  tests  that  establish  the  presence  of  a  drug-induced  liver  injury;  therefore,  the  diagnosis  is  often  one  of  exclusion.Evidence  of  hepatic  injury  appearing  days  to  months  after  adding  a  therapeutic  drug  with  known  or  suspected  potential  to  injure  the  liver  suggests  possible  drug-induced  injury.Improvement  following  discontinuation  of  a  drug  suspected  to  have  caused  liver  injury  (deceleration)  is  often  helpful  in  diagnosis.In  patients  with  few  if  any  signs  or  symptoms  of  liver  injury,  hepatotoxicity  may  be  detected  only  by  biochemical  tests  showing  elevated  aminotransferase,  bilirubin,  or  alkaline  phosphatase  levels.A  drug-induced  etiology  should  be  considered  in  any  patient  who  develops  acute  hepatitis  with  jaundice  (hepatocellular  injury)  or  jaundice  associated  with  pruritus  and  elevated  alkaline  phosphatase  levels  (cholestatic  or  mixed  injury).