RT Book, Section
A1 Kramer, Joel
A1 Seeley, William W.
A1 Miller, Bruce L.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1155958600
T1 Vascular Dementia
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1155958600
RD 2024/04/25
AB Vascular  cognitive  impairment  and  vascular  dementia  (VCI-VaD)  denote  deficits  in  cognition  and  behavior,  along  a  spectrum  of  severity,  that  are  associated  with  cerebrovascular  disease  (CVD).  A  dementia  syndrome  results  when  CVD  is  severe  enough  to  cause  significant  deficits  in  occupational,  social,  or  functional  abilities.  VaD  is  among  the  most  common  causes  of  dementia  in  the  elderly,  although  its  prevalence  is  disputed.  Vascular  disease  can  disrupt  structural  cognitive  networks  with  lesions  such  as  microinfarcts,  microbleeds,  macroinfarcts,  large  hemorrhages,  and  chronic  progressive  white  matter  degeneration,  as  well  as  altered  cerebral  hemodynamics,  such  as  hypoperfusion,  disrupted  cerebrovascular  autoregulation  (Chap.  301)  neurovascular  decoupling  (loss  of  normal  hemodynamic  responses  to  neural  activity),  and  blood  brain  barrier  dysfunction.  The  pathophysiological  underpinnings  of  VCI-VaD  remain  an  active  area  of  research.