RT Book, Section
A1 Stone, John H.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1156607178
T1 IgG4-Related Disease
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1156607178
RD 2024/04/19
AB IgG4-related  disease  (IgG4-RD)  is  a  fibroinflammatory  condition  characterized  by  a  tendency  to  form  tumefactive  lesions.  The  clinical  manifestations  of  this  disease,  however,  are  protean,  as  IgG4-RD  can  affect  virtually  any  organ  system.  Commonly  affected  organs  are  the  biliary  tree,  major  salivary  glands,  periorbital  tissues,  kidneys,  lungs,  lymph  nodes,  and  retroperitoneum.  In  addition,  IgG4-RD  involvement  of  the  meninges,  aorta,  prostate,  thyroid,  pericardium,  skin,  and  other  organs  is  well  described.  The  disease  is  believed  to  affect  the  brain  parenchyma,  the  joints,  the  bone  marrow,  and  the  bowel  mucosa  only  rarely.